What are the typical symptoms of paramyloidosis?
  • Sintomas da paramiloidose
Sensitive symptoms are usually the first to occur. Decrease or loss of temperature sensitivity (hot / cold), in addition to sensations such as tingling or numbness, or sensations of severe pain (such as burning) are the initial symptoms typical of paramyloidosis. These symptoms usually start in the feet and legs and gradually rise to the hands, gradually over the years.
As the first manifestation of the disease, people may still experience involuntary weight loss, changes in bowel habits (constipation or diarrhea), difficulty in digesting or sexual dysfunction.
Progressively these gastrointestinal changes become more accentuated with frequent diarrhea, nausea and vomiting, and urinary changes often manifesting as recurrent urinary infections. Dizziness or even fainting may occur with changes in position due to a decrease in blood pressure. Progressively, there is a decrease in muscle strength that starts in the feet and legs and progresses to the upper limbs at a later stage of the disease. The difficulties of the march are characterized in the initial phases by difficulty in raising the feet and the fingers being this reason of the typical march of "standing foot" (the foot hits the ground like a crack, noisy march).
Involvement of the heart may not cause symptoms at an early stage or may manifest as dizziness, palpitations due to cardiac conduction changes requiring pacemaker placement. Later, amyloid deposits in the heart muscle can cause heart failure. Certain genetic mutations are most strongly associated with heart disease.
Kidney involvement may occur in 1/3 of patients, especially when there is a family history of kidney problems. It may be an early manifestation of the disease in rare cases, but it is usually a late manifestation of the disease, leading to kidney failure and the need for dialysis.
Visual disturbances such as blurred vision, dry eye, glaucoma, or decreased visual acuity may occur in later stages of the disease, or early in association with some rare mutations.
If left untreated, the symptoms of the disease worsen, which ultimately results in death, which occurs on average 10-15 years after the onset of symptoms. Thus, early treatment supervised by a specialist physician experienced in paramyloidosis is important and can make a real difference for patients.
The treatments currently available may delay the course of the disease and preserve the patients' quality of life.
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